Oxylipin Response to Acute and Chronic Exercise: A Systematic Review

Metabolites

DavidC. Nieman¹  AparecidaM. Catai²  ÉtoreF. Signini²  ClaudioD. Silva²  CamilaA. Sakaguchi² 

[1] North Carolina Research Campus, Appalachian State University, Kannapolis, NC 28081, USA;Physical Therapy Department, Federal University of São Carlos, São Carlos, SP 13565-905, Brazil;

关键词: inflammation;    lipid mediators;    lipidomics;    metabolites;    metabolomics;    physical exercise;   

DOI  :  10.3390/metabo10060264

来源: DOAJ

【 摘 要 】

Oxylipins are oxidized compounds of polyunsaturated fatty acids that play important roles in the body. Recently, metabololipidomic-based studies using advanced mass spectrometry have measured the oxylipins generated during acute and chronic physical exercise and described the related physiological effects. The objective of this systematic review was to provide a panel of the primary exercise-related oxylipins and their respective functions in healthy individuals. Searches were performed in five databases (Cochrane, PubMed, Science Direct, Scopus and Web of Science) using combinations of the Medical Subject Headings (MeSH) terms: “Humans”, “Exercise”, “Physical Activity”, “Sports”, “Oxylipins”, and “Lipid Mediators”. An adapted scoring system created in a previous study from our group was used to rate the quality of the studies. Nine studies were included after examining 1749 documents. Seven studies focused on the acute effect of physical exercise while two studies determined the effects of exercise training on the oxylipin profile. Numerous oxylipins are mobilized during intensive and prolonged exercise, with most related to the inflammatory process, immune function, tissue repair, cardiovascular and renal functions, and oxidative stress.

【 授权许可】

Unknown