Mitochondrial DNA Damage and Diseases [version 1; referees: 1 approved, 2 approved with reservations]

F1000Research

Pushplata Singh¹  Gyanesh Singh²  Devika Chanu Khaidem²  Aman Kundu²  Chirag Chopra²  U C Pachouri² 

[1] Department of Medicine, Punjab Institute of Medical Sciences, Jalandhar, Punjab, India;School of Biotechnology and Biosciences, Lovely Professional University, Phagwara, Punjab, India;

关键词: Genomics;    Structure: Transcription & Translation;   

DOI  :  10.12688/f1000research.6665.1

来源: DOAJ

【 摘 要 】

Various endogenous and environmental factors can cause mitochondrial DNA (mtDNA) damage.  One of the reasons for enhanced mtDNA damage could be its proximity to the source of oxidants, and lack of histone-like protective proteins. Moreover, mitochondria contain inadequate DNA repair pathways, and, diminished DNA repair capacity may be one of the factors responsible for high mutation frequency of the mtDNA. mtDNA damage might cause impaired mitochondrial function, and, unrepaired mtDNA damage has been frequently linked with several diseases. Exploration of mitochondrial perspective of diseases might lead to a better understanding of several diseases, and will certainly open new avenues for detection, cure, and prevention of ailments.

【 授权许可】

Unknown