Bone Marrow Mesenchymal Stromal Cells: Identification, Classification, and Differentiation

Frontiers in Cell and Developmental Biology

Jiacan Su¹  Sicheng Wang²  Lipeng Wang³  Yingying Jing⁶  Qianmin Gao⁶  Biaotong Huang⁷ 

[1] Department of Orthopedics Trauma, Shanghai Changhai Hospital, Naval Medical University, Shanghai, China;Department of Orthopedics, Shanghai Zhongye Hospital, Shanghai, China;Institute of Translational Medicine, Shanghai University, Shanghai, China;School of Life Sciences, Shanghai University, Shanghai, China;School of Medicine, Shanghai University, Shanghai, China;Shanghai University Institute of Advanced Interdisciplinary Materials Science, Shanghai, China;Wenzhou Institute of Shanghai University, Wenzhou, China;

关键词: bone marrow mesenchymal stromal cells;    multipotent stem cells;    skeletal stem cells;    adipocyte lineage cells;    BMSC;   

DOI  :  10.3389/fcell.2021.787118

来源: DOAJ

【 摘 要 】

Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem cells, including osteochondral and adipocyte progenitors. Nevertheless, the identification and classification are still controversial, which limits their application. In recent years, by lineage tracing and single-cell sequencing, several new subgroups of BMSCs and their roles in normal physiological and pathological conditions have been clarified. Key regulators and mechanisms controlling the fate of BMSCs are being revealed. Cross-talk among subgroups of bone marrow mesenchymal cells has been demonstrated. In this review, we focus on recent advances in the identification and classification of BMSCs, which provides important implications for clinical applications.

【 授权许可】

Unknown