Case Report: Primary Cardiac T-Cell Lymphoma With Complete Atrio-Ventricular Block Diagnosed by Endomyocardial Biopsy

Frontiers in Immunology

Wenbin Qian³  Yang Xu³  Panpan Chen³  Yuanyuan Hao³  Xibin Xiao³  Xi Qiu³  Wei Zhu⁴ 

[1] Department of Cardiology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China;Department of Hematology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China;Key Laboratory for Cancer Molecular Cell Biology, Life Sciences Institute, Zhejiang University, Hangzhou, China;Provincial Key Laboratory of Cardiovascular Research, Hangzhou, China;

关键词: primary cardiac lymphoma;    T-cell lymphoma;    complete atrioventricular block;    immunotherapy;    case report;   

DOI  :  10.3389/fimmu.2022.890059

来源: DOAJ

【 摘 要 】

Primary cardiac lymphoma (PCL) is a rare disease, the definite diagnosis of which is sometimes difficult and mainly relies on endomyocardial biopsy. Primary cardiac T-cell lymphoma (PCTL) is an extremely rare sub-type of PCL. Here, we report on a 47-year-old female with PCTL who presented with fever, syncope, palpitations, and a third-degree atrioventricular block (AVB) on electrocardiogram. Chemotherapy was administered with two courses of methotrexate, cyclophosphamide, liposomal doxorubicin, vincristine, and dexamethasone (MTX-CHOP). As the tumor vanished, AVB changed from third degree to second degree and finally to sinus rhythm. In conclusion, endomyocardial biopsy is valuable in the diagnosis of primary cardiac lymphoma. It is worth noting that alterations in the electrocardiogram may indicate an attack on the heart by PCTL.

【 授权许可】

Unknown