Role of Dendritic Cells in Viral Brain Infections

Frontiers in Immunology

Ghizlane Maarifi¹  Fabien P. Blanchet¹  Orianne Constant²  Philippe Van de Perre²  Sara Salinas²  Yannick Simonin² 

[1]Institut de Recherche en Infectiologie de Montpellier, Centre national de la recherche scientifique (CNRS), Université de Montpellier, Montpellier, France

[2]Pathogenesis and Control of Chronic and Emerging Infections, Institut national de la santé et de la recherche médicale (INSERM), University of Montpellier, Etablissement Français du Sang, Montpellier, France

关键词: viral infection;    dendritic cell;    blood–brain barrier;    neuroinflammation;    neuroinfections;    blood–cerebrospinal barrier;   

DOI  :  10.3389/fimmu.2022.862053

来源: DOAJ

【 摘 要 】

To gain access to the brain, a so-called immune-privileged organ due to its physical separation from the blood stream, pathogens and particularly viruses have been selected throughout evolution for their use of specific mechanisms. They can enter the central nervous system through direct infection of nerves or cerebral barriers or through cell-mediated transport. Indeed, peripheral lymphoid and myeloid immune cells can interact with the blood–brain and the blood–cerebrospinal fluid barriers and allow viral brain access using the “Trojan horse” mechanism. Among immune cells, at the frontier between innate and adaptive immune responses, dendritic cells (DCs) can be pathogen carriers,regulate or exacerbate antiviral responses and neuroinflammation, and therefore be involved in viral transmission and spread. In this review, we highlight an important contribution of DCs in the development and the consequences of viral brain infections.

【 授权许可】

Unknown