The Value of APTw CEST MRI in Routine Clinical Assessment of Human Brain Tumor Patients at 3T

Diagnostics

Andrej Pala¹  Michael Braun²  Soung Yung Kim²  Johannes Rosskopf²  Julia P. Lingl²  Bernd L. Schmitz²  Meinrad Beer²  Arthur Wunderlich²  Mark E. Ladd³  Steffen Goerke³  Daniel Paech⁴  Patrick Liebig⁵ 

[1] Department of Neurosurgery, Bezirkskrankenhaus Guenzburg, Lindenallee 2, 89312 Guenzburg, Germany;Department of Radiology, Ulm University, Albert-Einstein-Allee 23, 89081 Ulm, Germany;German Cancer Research Center (DKFZ), Department of Medical Physics in Radiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;German Cancer Research Center (DKFZ), Division of Radiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany;Siemens Healthcare GmbH, Henkestraße 127, 91052 Erlangen, Germany;

关键词: CEST;    APTw;    brain tumor;    MRI;   

DOI  :  10.3390/diagnostics12020490

来源: DOAJ

【 摘 要 】

Background. With fast-growing evidence in literature for clinical applications of chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI), this prospective study aimed at applying amide proton transfer-weighted (APTw) CEST imaging in a clinical setting to assess its diagnostic potential in differentiation of intracranial tumors at 3 tesla (T). Methods. Using the asymmetry magnetization transfer ratio (MTRasym) analysis, CEST signals were quantitatively investigated in the tumor areas and in a similar sized region of the normal-appearing white matter (NAWM) on the contralateral hemisphere of 27 patients with intracranial tumors. Area under curve (AUC) analyses were used and results were compared to perfusion-weighted imaging (PWI). Results. Using APTw CEST, contrast-enhancing tumor areas showed significantly higher APTw CEST metrics than contralateral NAWM (AUC = 0.82; p < 0.01). In subgroup analyses of each tumor entity vs. NAWM, statistically significant effects were yielded for glioblastomas (AUC = 0.96; p < 0.01) and for meningiomas (AUC = 1.0; p < 0.01) but not for lymphomas as well as metastases (p > 0.05). PWI showed results comparable to APTw CEST in glioblastoma (p < 0.01). Conclusions. This prospective study confirmed the high diagnostic potential of APTw CEST imaging in a routine clinical setting to differentiate brain tumors.

【 授权许可】

Unknown