期刊论文详细信息
Frontiers in Oncology
The Risk Factors, Incidence and Prognosis of Postpartum Breast Cancer: A Nationwide Study by the SMARTSHIP Group
Ho Hur1  Joon Jeong2  Kweon-Cheon Kim3  Soo Youn Bae4  Nam Hyoung Kim5  Ji Sung Lee6  Jae Sun Yoon7  Jung Eun Lee8  Sungmin Park9  Hyun Jo Youn1,10  Jihyoun Lee1,11  Jong Won Lee1,12  Seho Park1,13 
[1] 0Department of Surgery, National Health Insurance Service Ilsan Hospital, Koyang-si, South Korea;1Department of Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea;2Department of Surgery, Chosun University Medical School, Gwangju, South Korea;3Department of Surgery, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, South Korea;Advertising and Branding, Kaywon University of Art and Design, Uiwang-si, South Korea;Clinical Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea;Department of Biostatistics, Korea University, Seoul, South Korea;Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul, South Korea;Department of Surgery, Chungbuk National University Hospital, College of Medicine, Chungbuk National University, Cheongju, South Korea;Department of Surgery, Jeonbuk National University Medical School, Jeonju, South Korea;Department of Surgery, Soonchunhyang University Seoul Hospital, Seoul, South Korea;Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea;Division of Breast Surgery, Department of Surgery, Yonsei University College of Medicine, Seoul, South Korea;
关键词: breast neoplasm;    postpartum;    pregnancy;    delivery;    gestational;    diabetes;   
DOI  :  10.3389/fonc.2022.889433
来源: DOAJ
【 摘 要 】

The term ‘pregnancy-associated breast cancer’ is no longer used as it has been consistently reported that breast cancer during pregnancy and breast cancer after delivery (postpartum breast cancer) have different characteristics and prognosis. The purpose of this study is to define postpartum breast cancer by analyzing the incidence rate, related factors, and prognosis according to the timing of breast cancer. Data from the Korean National Health Insurance Service were used to analyze 1,292,727 women aged 20-49 years who birthed their first child between 2007 and 2012. The annual incidence rate of breast cancer after delivery increased every year (7.7 per 10,000 person-years after 5 years, 19.36 per 10,000 person-years after 10 years). The risk of breast cancer was significantly higher (hazard ratio 1.15, 95% CI 1.05-1.27, P=0.0037) in women diagnosed with gestational diabetes, but that was not associated with overall survival (OS). Patients diagnosed with breast cancer within 5 years of delivery had a poorer prognosis than those diagnosed later (5-year OS, <5 years: 91.1% vs. 5-10 years: 96.0%). In multivariate analysis of OS, the hazard ratio of patients diagnosed within 5 years after delivery was twice as high as of patients diagnosed between 5 and 10 years. Women diagnosed with gestational diabetes had an increased risk of breast cancer. Breast cancer patients diagnosed within 5 years of delivery had a poorer prognosis than those diagnosed later. In this regard, careful screening for early diagnosis of high-risk patients and intensive research on new treatment strategies are needed.

【 授权许可】

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