Overcoming the penetration depth limit in optical microscopy: Adaptive optics and wavefront shaping

Journal of Innovative Optical Health Sciences

Taeseong Woo¹  Kibum Nam¹  Byungjae Hwang¹  Cheolwoo Ahn¹  Jung-Hoon Park¹  Hyungwon Jin¹ 

[1] Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea;

关键词: Adaptive optics;    wavefront shaping;    optical aberration;    multiple scattering;    in-vivo imaging;   

DOI  :  10.1142/S1793545819300027

来源: DOAJ

【 摘 要 】

Despite the unique advantages of optical microscopy for molecular specific high resolution imaging of living structure in both space and time, current applications are mostly limited to research settings. This is due to the aberrations and multiple scattering that is induced by the inhomogeneous refractive boundaries that are inherent to biological systems. However, recent developments in adaptive optics and wavefront shaping have shown that high resolution optical imaging is not fundamentally limited only to the observation of single cells, but can be significantly enhanced to realize deep tissue imaging. To provide insight into how these two closely related fields can expand the limits of bio imaging, we review the recent progresses in their performance and applicable range of studies as well as potential future research directions to push the limits of deep tissue imaging.

【 授权许可】

Unknown