Cohesin Mutations in Cancer: Emerging Therapeutic Targets

International Journal of Molecular Sciences

Julia A. Horsfield¹  Chue Vin Chin¹  Jisha Antony¹ 

[1] Department of Pathology, Otago Medical School, University of Otago, Dunedin 9016, New Zealand;

关键词: cohesin;    cancer;    therapeutics;    transcription;    synthetic lethal;   

DOI  :  10.3390/ijms22136788

来源: DOAJ

【 摘 要 】

The cohesin complex is crucial for mediating sister chromatid cohesion and for hierarchal three-dimensional organization of the genome. Mutations in cohesin genes are present in a range of cancers. Extensive research over the last few years has shown that cohesin mutations are key events that contribute to neoplastic transformation. Cohesin is involved in a range of cellular processes; therefore, the impact of cohesin mutations in cancer is complex and can be cell context dependent. Candidate targets with therapeutic potential in cohesin mutant cells are emerging from functional studies. Here, we review emerging targets and pharmacological agents that have therapeutic potential in cohesin mutant cells.

【 授权许可】

Unknown