The Complexities of Metastasis

Cancers

MariaJ. Garcia-Leon¹  JackyG. Goetz¹  BeatrizP. San Juan²  ChristineL. Chaffer²  Laura Rangel² 

[1] INSERM UMR_S1109, Tumor Biomechanics, 67000 Strasbourg, France;The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst 2010, Australia;

关键词: metastasis;    heterogeneity;    plasticity;    epithelial-to-mesenchymal transition;    biomechanics;    circulating tumor cells (ctcs);    extracellular vesicles;    metastatic niche;    epigenetics;    ctc-clusters;   

DOI  :  10.3390/cancers11101575

来源: DOAJ

【 摘 要 】

Therapies that prevent metastatic dissemination and tumor growth in secondary organs are severely lacking. A better understanding of the mechanisms that drive metastasis will lead to improved therapies that increase patient survival. Within a tumor, cancer cells are equipped with different phenotypic and functional capacities that can impact their ability to complete the metastatic cascade. That phenotypic heterogeneity can be derived from a combination of factors, in which the genetic make-up, interaction with the environment, and ability of cells to adapt to evolving microenvironments and mechanical forces play a major role. In this review, we discuss the specific properties of those cancer cell subgroups and the mechanisms that confer or restrict their capacity to metastasize.

【 授权许可】

Unknown