Cancers | |
The Complexities of Metastasis | |
MariaJ. Garcia-Leon1  JackyG. Goetz1  BeatrizP. San Juan2  ChristineL. Chaffer2  Laura Rangel2  | |
[1] INSERM UMR_S1109, Tumor Biomechanics, 67000 Strasbourg, France;The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Darlinghurst 2010, Australia; | |
关键词: metastasis; heterogeneity; plasticity; epithelial-to-mesenchymal transition; biomechanics; circulating tumor cells (ctcs); extracellular vesicles; metastatic niche; epigenetics; ctc-clusters; | |
DOI : 10.3390/cancers11101575 | |
来源: DOAJ |
【 摘 要 】
Therapies that prevent metastatic dissemination and tumor growth in secondary organs are severely lacking. A better understanding of the mechanisms that drive metastasis will lead to improved therapies that increase patient survival. Within a tumor, cancer cells are equipped with different phenotypic and functional capacities that can impact their ability to complete the metastatic cascade. That phenotypic heterogeneity can be derived from a combination of factors, in which the genetic make-up, interaction with the environment, and ability of cells to adapt to evolving microenvironments and mechanical forces play a major role. In this review, we discuss the specific properties of those cancer cell subgroups and the mechanisms that confer or restrict their capacity to metastasize.
【 授权许可】
Unknown