Intrinsic and Extrinsic Modulators of the Epithelial to Mesenchymal Transition: Driving the Fate of Tumor Microenvironment

Frontiers in Oncology

Federica Collino¹  Benedetta Bussolati³  Francesca Sensi⁴  Rafael Soares Lindoso⁵  Salvatore Pucciarelli⁶  Edoardo D'Angelo⁸  Marco Agostini⁸ 

[1] 0Pediatric Nephrology, Dialysis and Transplant Unit, Fondazione Ca' Granda, IRCCS Policlinico di Milano, Milan, Italy;Department of Biomedical Sciences, University of Padova, Padua, Italy;Department of Medical Sciences, Molecular Biotechnology Center, University of Torino, Turin, Italy;Department of Molecular Sciences and Nanosystems, Cà Foscari University of Venice, Venice, Italy;Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, Netherlands;First Surgical Clinic, Department of Surgery, Oncology and Gastroenterology, University of Padova, Padua, Italy;Institute of Biophysics Carlos Chagas Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;Institute of Pediatric Research, Fondazione Citta della Speranza, Padua, Italy;LIFELAB Program, Consorzio per la Ricerca Sanitaria–CORIS, Veneto Region, Padua, Italy;National Institute of Science and Technology for Regenerative Medicine–REGENERA, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil;

关键词: epithelial to mesenchymal transition;    tumor microenvironment;    extracellular matrix;    extracellular vesicles;    personalized medicine;   

DOI  :  10.3389/fonc.2020.01122

来源: DOAJ

【 摘 要 】

The epithelial to mesenchymal transition (EMT) is an evolutionarily conserved process. In cancer, EMT can activate biochemical changes in tumor cells that enable the destruction of the cellular polarity, leading to the acquisition of invasive capabilities. EMT regulation can be triggered by intrinsic and extrinsic signaling, allowing the tumor to adapt to the microenvironment demand in the different stages of tumor progression. In concomitance, tumor cells undergoing EMT actively interact with the surrounding tumor microenvironment (TME) constituted by cell components and extracellular matrix as well as cell secretome elements. As a result, the TME is in turn modulated by the EMT process toward an aggressive behavior. The current review presents the intrinsic and extrinsic modulators of EMT and their relationship with the TME, focusing on the non-cell-derived components, such as secreted metabolites, extracellular matrix, as well as extracellular vesicles. Moreover, we explore how these modulators can be suitable targets for anticancer therapy and personalized medicine.

【 授权许可】

Unknown