Risk of childhood asthma following prenatal exposure to negative life events and job stressors: A nationwide register-based study in Denmark

Scandinavian Journal of Work, Environment & Health

Henrik A Kolstad¹  Karin Sørig Hougaard¹  Jørn Olsen¹  Kirsten Skamstrup Hansen¹  Vivi Schlünssen¹  Niklas Worm Andersson¹  Jens Peter Ellekilde Bonde¹  Kathrine Pape Madsen¹  Camilla Sandal Sejbaek¹  Reiner Rugulies¹  Xiaoqin Liu² 

[1] ;Xiaoqin Liu, The National Center for Register-based Research, Aarhus University, Fuglesangs Allé 26, 8210 Aarhus V, Denmark.;

关键词: prenatal exposure;    job stressor;    childhood asthma;    phenotype;    stress;    cohort;    asthma;    cohort study;    work stress;    job stress;    job control;    job demand;    denmark;    stressor;    register-based study;    life event;   

DOI  :  10.5271/sjweh.3785

来源: DOAJ

【 摘 要 】

OBJECTIVES: This study aimed to examine the association between negative life events, job stressors (low job control or high psychosocial job demands) and offspring asthma phenotypes (early-onset transient, early-onset persistent and late-onset asthma). METHODS: In a population-based cohort study comprising 547 533 liveborn singletons, we determined negative life events and offspring asthma at age six years using data from Danish nationwide registers. We assessed job demands and job control from gender-specific job exposure matrices. Prevalence ratios (PR) of each asthma phenotype were estimated using log-binomial regression. RESULTS: Maternal exposure to negative life events prenatally was not significantly associated with offspring asthma. Among mothers with low job demands, low job control was associated with increased risk for early-onset transient asthma [PR=1.14, 95% confidence interval (CI) 1.09–1.19], early-onset persistent asthma (PR=1.17, 95% CI 1.11–1.23), and late-onset asthma (PR=1.06, 95% CI 1.00–1.14). Among mothers with high job demands, low job control was not associated with offspring asthma apart from a reduced risk of early-onset persistent asthma (PR=0.94, 95% CI 0.90–0.97). These associations were independent of child sex and parental atopic history. CONCLUSIONS: Maternal stressors in private life do not seem to influence offspring asthma significantly. Low job control is associated with offspring asthma, which is modified by maternal psychosocial job demands. Our findings warrant further exploration.

【 授权许可】

Unknown