Selection on mutators is not frequency-dependent

eLife

Daniel Weinreich¹  Yevgeniy Raynes¹ 

[1] Department of Ecology and Evolutionary Biology, Center for Computational Molecular Biology, Brown University, Providence, United States;

关键词: mutation rate;    mutator;    indirect selection;   

DOI  :  10.7554/eLife.51177

来源: DOAJ

【 摘 要 】

The evolutionary fate of mutator mutations – genetic variants that raise the genome-wide mutation rate – in asexual populations is often described as being frequency (or number) dependent. Mutators can invade a population by hitchhiking with a sweeping beneficial mutation, but motivated by earlier experiments results, it has been repeatedly suggested that mutators must be sufficiently frequent to produce such a driver mutation before non-mutators do. Here, we use stochastic, agent-based simulations to show that neither the strength nor the sign of selection on mutators depend on their initial frequency, and while the overall probability of hitchhiking increases predictably with frequency, the per-capita probability of fixation remains unchanged.

【 授权许可】

Unknown