Bioactive NIR‐II Light‐Responsive Shape Memory Composite Based on Cuprorivaite Nanosheets for Endometrial Regeneration

Advanced Science

Xueqing Wu¹  Xingdi Qiu¹  Peng Huang¹  Hao Wang¹  Wenli Hong¹  Chenle Dong¹  Chen Yang²  Muhammad Rizwan Younis²  Jing Zhang²  Dong‐Yang Zhang²  Gang He²  Lian‐Hua Fu²  Jing Lin² 

[1] Department of Obstetrics and Gynecology The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang 325000 China;Marshall Laboratory of Biomedical Engineering International Cancer Center Laboratory of Evolutionary Theranostics (LET) School of Biomedical Engineering Shenzhen University Health Science Center Shenzhen 518060 China;

关键词: cuprorivaite nanosheets;    endometrial regeneration;    intrauterine adhesions;    NIR‐II light‐responsive;    shape memory;   

DOI  :  10.1002/advs.202102220

来源: DOAJ

【 摘 要 】

Abstract Intrauterine adhesions (IUAs) caused by mechanical damage or infection increase the risk of infertility in women. Although numerous physical barriers such as balloon or hydrogel are developed for the prevention of IUAs, the therapeutic efficacy is barely satisfactory due to limited endometrial healing, which may lead to recurrence. Herein, a second near‐infrared (NIR‐II) light‐responsive shape memory composite based on the combination of cuprorivaite (CaCuSi4O10) nanosheets (CUP NSs) as photothermal conversion agents and polymer poly(d,l‐lactide‐co‐trimethylene carbonate) (PT) as shape memory building blocks is developed. The as‐prepared CUP/PT composite possesses excellent shape memory performance under NIR‐II light, and the improved operational feasibility as an antiadhesion barrier for the treatment of IUAs. Moreover, the released ions (Cu, Si) can stimulate the endometrial regeneration due to the angiogenic bioactivity. This study provides a new strategy to prevent IUA and restore the injured endometrium relied on shape memory composite with enhanced tissues reconstruction ability.

【 授权许可】

Unknown