Stress Marks on the Genome: Use or Lose?

International Journal of Molecular Sciences

Sudha Sharma¹  Bayan Bokhari¹ 

[1] Department of Biochemistry and Molecular Biology, College of Medicine, Howard University, 520 W Street, NW, Washington, DC 20059, USA;

关键词: oxidative stress;    DNA damage;    DNA repair;    replication;    8-oxoG;    epigenetic;    gene expression;    helicase;   

DOI  :  10.3390/ijms20020364

来源: DOAJ

【 摘 要 】

Oxidative stress and the resulting damage to DNA are inevitable consequence of endogenous physiological processes further amplified by cellular responses to environmental exposures. If left unrepaired, oxidative DNA lesions can block essential processes such as transcription and replication or can induce mutations. Emerging data also indicate that oxidative base modifications such as 8-oxoG in gene promoters may serve as epigenetic marks, and/or provide a platform for coordination of the initial steps of DNA repair and the assembly of the transcriptional machinery to launch adequate gene expression alterations. Here, we briefly review the current understanding of oxidative lesions in genome stability maintenance and regulation of basal and inducible transcription.

【 授权许可】

Unknown