The multi-functional roles of forkhead box protein O in skin aging and diseases

Redox Biology

Hyeung-Rak Kim¹  Bonggi Lee²  Min Soo Kim³  Kyoung Mi Moon⁴  Taehyeok Hwang⁴  Min-Kyeong Lee⁵  Chun Whan Choi⁶ 

[1] Division of Bio-Medical Science &Technology, KIST School, University of Science and Technology, Seoul, 02792, Republic of Korea;Brain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, 02792, Republic of Korea;College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju, Republic of Korea;Department of Food Science and Nutrition, Pukyong National University, Nam-Gu, Busan, Republic of Korea;Natural Product Research Team, Biocenter, Gyeonggido Business and Science Accelerator, Gyeonggi-Do, Republic of Korea;

关键词: FoxOs;    Melanogenesis;    Wound healing;    Acne;    Melanoma;   

DOI  :  

来源: DOAJ

【 摘 要 】

Forkhead box, class O (FoxO) family members are multifunctional transcription factors that are involved in several metabolic processes, including energy metabolism, apoptosis, DNA repair, and oxidative stress. However, their roles in skin health have not been well-documented. Recent studies have indicated that FoxOs are important factors to control skin homeostasis and health. The activation or deactivation of some FoxO family members is closely related to melanogenesis, wound healing, acne, and melanoma. In this review, we have discussed the recent findings that demonstrate the relationship between FoxOs and skin health as well as the underlying mechanisms associated with their functions.

【 授权许可】

Unknown