KRAS/BRAF Analysis in Ovarian Low-Grade Serous Carcinoma Having Synchronous All Pathological Precursor Regions

International Journal of Molecular Sciences

Masako Ishikawa¹  Razia Sultana¹  Kohei Nakamura¹  Kentaro Nakayama¹  Emi Sato¹  Hiroshi Katagiri¹  Kouji Iida¹  Satoru Kyo¹  Toshiko Minamoto¹  Kaori Sanuki¹  Tomoka Ishibashi¹  Hitomi Yamashita¹  Noriyoshi Ishikawa² 

[1] Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo 6938501, Japan;Department of Organ Pathology, Shimane University School of Medicine, Izumo 6938501, Japan;

关键词: low-grade serous carcinoma;    KRAS;    BRAF;    mutation;   

DOI  :  10.3390/ijms17050625

来源: DOAJ

【 摘 要 】

Ovarian low-grade serous carcinoma is thought to begin as a serous cystadenoma or adenofibroma that progresses in a slow stepwise fashion. Among the low-grade serous carcinomas, there is a high frequency of activating mutations in the KRAS or BRAF genes; however, it remains unclear as to how these mutations contribute to tumor progression. This is the first report to track the histopathological progression of serous adenofibroma to low-grade serous carcinoma. Each stage was individually analyzed by pathological and molecular genetic methods to determine what differences occur between the distinct stages of progression.

【 授权许可】

Unknown