Annual and seasonal patterns in etiologies of pediatric community-acquired pneumonia due to respiratory viruses and Mycoplasma pneumoniae requiring hospitalization in South Korea

BMC Infectious Diseases

Pneumonia and Respiratory Disease Study Group of Korean Academy of Pediatric Allergy and Respiratory Disease¹  Hyo-Bin Kim²  Chang-Keun Kim²  Jinho Yu³  Man Yong Han⁴  Hai Lee Chung⁵  Yoon-Young Jang⁵  Eun Lee⁶  Eun Hee Chung⁷  Jin Tack Kim⁸  Ju-Hee Seo⁹  Sung-Min Choi^1,10  Young Min Ahn^1,11  In Suk Sol^1,12  Yong Ju Lee^1,13  Kyung Suk Lee^1,14  Min Seob Song^1,15  Jung Yeon Shim^1,16  Hea Lin Oh^1,17  Dae Jin Song^1,18  Gwang Cheon Jang^1,19  Sungsu Jung^2,20  Hyung Young Kim^2,20  Chul-Hong Kim^2,21  Ju Suk Lee^2,21  Yun Jung Choi^2,22  Myongsoon Sung^2,23  Bong-Seong Kim^2,24  Yunsun Kim^2,25  Hyeon-Jong Yang^2,25  Chorong Park^2,25  Sangyoung Kim^2,25 

[1] ;Asthma and Allergy Center, Department of Pediatrics, Inje University Sanggye Paik Hospital;Department of Pediatrics, Asan Medical Center, Ulsan University Medical School;Department of Pediatrics, CHA Bundang Medical Center, CHA University School of Medicine;Department of Pediatrics, Catholic University of Daegu School of Medicine;Department of Pediatrics, Chonnam National University Hospital, Chonnam National University Medical School;Department of Pediatrics, Chungnam National University Hospital, Chungnam National University School of Medicine;Department of Pediatrics, College of Medicine, The Catholic University of Korea;Department of Pediatrics, Dankook University Hospital, Dankook University Medical School;Department of Pediatrics, Dongguk University Kyungju Hospital;Department of Pediatrics, Eulji University, Eulji General Hospital;Department of Pediatrics, Hallym University Chuncheon Sacred Heart Hospital;Department of Pediatrics, Hallym University Kangnam Sacred Heart Hospital;Department of Pediatrics, Hanyang University Guri Hospital, Hanyang University College of Medicine;Department of Pediatrics, Inje University Haeundae Paik Hospital;Department of Pediatrics, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine;Department of Pediatrics, Korea Cancer Center Hospital;Department of Pediatrics, Korea University Guro Hospital, Korea University College of Medicine;Department of Pediatrics, National Health Insurance Service, Ilsan Hospital;Department of Pediatrics, Pusan National University Children’s Hospital;Department of Pediatrics, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine;Department of Pediatrics, Seoul National University Children Hospital;Department of Pediatrics, Soonchunhyang University Gumi Hospital;Department of Pediatrics, Ulsan University Gangneung Asan Hospital;SCH Biomedical Informatics Research Unit, Soonchunhyang University Seoul Hospital;

关键词: Children;    Pneumonia;    Respiratory virus;    Mycoplasma pneumoniae;    Macrolide- refractory;    Macrolide-sensitive;   

DOI  :  10.1186/s12879-020-4810-9

来源: DOAJ

【 摘 要 】

Abstract Background Community–acquired pneumonia (CAP) is one of the leading worldwide causes of childhood morbidity and mortality. Its disease burden varies by age and etiology and is time dependent. We aimed to investigate the annual and seasonal patterns in etiologies of pediatric CAP requiring hospitalization. Methods We conducted a retrospective study in 30,994 children (aged 0–18 years) with CAP between 2010 and 2015 at 23 nationwide hospitals in South Korea. Mycoplasma pneumoniae (MP) pneumonia was clinically classified as macrolide-sensitive MP, macrolide-less effective MP (MLEP), and macrolide-refractory MP (MRMP) based on fever duration after initiation of macrolide treatment, regardless of the results of in vitro macrolide sensitivity tests. Results MP and respiratory syncytial virus (RSV) were the two most commonly identified pathogens of CAP. With the two epidemics of MP pneumonia (2011 and 2015), the rates of clinical MLEP and MRMP pneumonia showed increasing trends of 36.4% of the total MP pneumonia. In children < 2 years of age, RSV (34.0%) was the most common cause of CAP, followed by MP (9.4%); however, MP was the most common cause of CAP in children aged 2–18 years of age (45.3%). Systemic corticosteroid was most commonly administered for MP pneumonia. The rate of hospitalization in intensive care units was the highest for RSV pneumonia, and ventilator care was most commonly needed in cases of adenovirus pneumonia. Conclusions The present study provides fundamental data to establish public health policies to decrease the disease burden due to CAP and improve pediatric health.

【 授权许可】

Unknown