The Complex Role of Store Operated Calcium Entry Pathways and Related Proteins in the Function of Cardiac, Skeletal and Vascular Smooth Muscle Cells

Frontiers in Physiology

Javier Avila-Medina¹  Tarik Smani¹  Alejandro Dominguez-Rodriguez¹  Juan A. Rosado²  Juan Ribas³  Isabel Gallardo-Castillo⁴  Isabel Mayoral-Gonzalez⁵  Antonio Ordoñez⁵ 

[1] CIBERCV, Madrid, Spain;Cell Physiology Research Group, Department of Physiology, Institute of Molecular Pathology Biomarkers, University of Extremadura, Cáceres, Spain;Department of Medical Physiology and Biophysics, University of Seville, Sevilla, Spain;Department of Stomatology, School of Dentistry, University of Seville, Sevilla, Spain;Department of Surgery, University of Seville, Sevilla, Spain;Institute of Biomedicine of Seville, University Hospital of Virgen del Rocío, CSIC, University of Seville, Sevilla, Spain;

关键词: Ca2+;    Orai;    STIM;    TRPC;    cardiomyocyte;    skeletal muscle;   

DOI  :  10.3389/fphys.2018.00257

来源: DOAJ

【 摘 要 】

Cardiac, skeletal, and smooth muscle cells shared the common feature of contraction in response to different stimuli. Agonist-induced muscle's contraction is triggered by a cytosolic free Ca2+ concentration increase due to a rapid Ca2+ release from intracellular stores and a transmembrane Ca2+ influx, mainly through L-type Ca2+ channels. Compelling evidences have demonstrated that Ca2+ might also enter through other cationic channels such as Store-Operated Ca2+ Channels (SOCCs), involved in several physiological functions and pathological conditions. The opening of SOCCs is regulated by the filling state of the intracellular Ca2+ store, the sarcoplasmic reticulum, which communicates to the plasma membrane channels through the Stromal Interaction Molecule 1/2 (STIM1/2) protein. In muscle cells, SOCCs can be mainly non-selective cation channels formed by Orai1 and other members of the Transient Receptor Potential-Canonical (TRPC) channels family, as well as highly selective Ca2+ Release-Activated Ca2+ (CRAC) channels, formed exclusively by subunits of Orai proteins likely organized in macromolecular complexes. This review summarizes the current knowledge of the complex role of Store Operated Calcium Entry (SOCE) pathways and related proteins in the function of cardiac, skeletal, and vascular smooth muscle cells.

【 授权许可】

Unknown