Drosophila as a model to explore secondary injury cascades after traumatic brain injury

Biomedicine & Pharmacotherapy

Theresa Currier Thomas¹  Gokul Krishna²  Lori M. Buhlman³  T. Bucky Jones⁴ 

[1] Barrow Neurological Institute at Phoenix Children’s Hospital, Phoenix, AZ, USA;Correspondence to: College of Graduate Studies, Midwestern University Glendale, USA.;Biomedical Sciences Program, Midwestern University, Glendale, AZ, USA;Department of Child Health, University of Arizona College of Medicine - Phoenix, Phoenix, AZ, USA;

关键词: Traumatic brain injury;    Drosophila;    Secondary injury;    Inflammation;    Innate immunity;    Oxidative stress;   

DOI  :  

来源: DOAJ

【 摘 要 】

Drosophilae are emerging as a valuable model to study traumatic brain injury (TBI)-induced secondary injury cascades that drive persisting neuroinflammation and neurodegenerative pathology that imposes significant risk for long-term neurological deficits. As in mammals, TBI in Drosophila triggers axonal injury, metabolic crisis, oxidative stress, and a robust innate immune response. Subsequent neurodegeneration stresses quality control systems and perpetuates an environment for neuroprotection, regeneration, and delayed cell death via highly conserved cell signaling pathways. Fly injury models continue to be developed and validated for both whole-body and head-specific injury to isolate, evaluate, and modulate these parallel pathways. In conjunction with powerful genetic tools, the ability for longitudinal evaluation, and associated neurological deficits that can be tested with established behavioral tasks, Drosophilae are an attractive model to explore secondary injury cascades and therapeutic intervention after TBI. Here, we review similarities and differences between mammalian and fly pathophysiology and highlight strategies for their use in translational neurotrauma research.

【 授权许可】

Unknown