microRNAs and Cardiac Cell Fate

Cells

Chiara Piubelli¹  Viviana Meraviglia¹  Alessandra Rossini¹  Yuri D'Alessandra²  Gualtiero I. Colombo²  Giulio Pompilio² 

[1] Center for Biomedicine, European Academy of Bolzano/Bozen, Via Galvani 31, I-39100 Bolzano, Italy;Centro Cardiologico Monzino, IRCCS, Via Parea 4, I-20138 Milano, Italy;

关键词: microRNA;    pluripotency;    cardiomyocytes;    cardiac reprogramming;    cardiac development;   

DOI  :  10.3390/cells3030802

来源: DOAJ

【 摘 要 】

The role of small, non-coding microRNAs (miRNAs) has recently emerged as fundamental in the regulation of the physiology of the cardiovascular system. Several specific miRNAs were found to be expressed in embryonic, postnatal, and adult cardiac tissues. In the present review, we will provide an overview about their role in controlling the different pathways regulating cell identity and fate determination. In particular, we will focus on the involvement of miRNAs in pluripotency determination and reprogramming, and specifically on cardiac lineage commitment and cell direct transdifferentiation into cardiomyocytes. The identification of cardiac-specific miRNAs and their targets provide new promising insights into the mechanisms that regulate cardiac development, function and dysfunction. Furthermore, due to their contribution in reprogramming, they could offer new opportunities for developing safe and efficient cell-based therapies for cardiovascular disorders.

【 授权许可】

Unknown