Transcranial Magnetic Stimulation to the Middle Frontal Gyrus During Attention Modes Induced Dynamic Module Reconfiguration in Brain Networks

Frontiers in Neuroinformatics

Yuping Wang¹  Chunyan Liu³  Qing Xue³  Yicong Lin³  Penghui Song³  Hua Lin³  Peng Xu⁴  Yuanling Jiang⁴ 

[1] Beijing Key Laboratory of Neuromodulation, Beijing, China;Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China;Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China;Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China;

关键词: middle frontal gyrus;    TMS-EEG;    attention;    time-varying network;    reorganization;   

DOI  :  10.3389/fninf.2019.00022

来源: DOAJ

【 摘 要 】

The interaction between dorsal and ventral attention networks (VANs) is mediated by the middle frontal gyrus (MFG), which is functionally connected to both networks. However, the direct role of the MFG in selective and sustained attention remains controversial. In the current study, we used transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to probe the connectivity dynamic changes of MFG-associated regions during different attention modes. The participants underwent visual, selective, and sustained attention tasks to observe TMS-induced network changes. Twenty healthy participants received single-pulse TMS over the left or right MFG during tasks, while synchronous EEG data was acquired. Behavioral results were recorded and time-varying brain network analyses were performed. We found that the MFG is involved in attention processing and that sustained attention was preferentially controlled by the right MFG. Moreover, compared with the right hemisphere, the left hemisphere was associated with selective attention tasks. Visual and selective attention tasks induced MFG-related changes in network nodes were within the left hemisphere; however, sustained attention induced changes in network nodes were in the bilateral posterior MFG. Our findings indicated that the MFG plays a crucial role in regulating attention networks. In particular, TMS-induced MFG alterations influenced key nodes of the time-varying brain network, leading to the reorganization of brain network modules.

【 授权许可】

Unknown