Rationally Programming Nanomaterials with DNA for Biomedical Applications

Advanced Science

Oleg Gang¹  Jing Mu²  Liangcan He³  Xiaoyuan Chen³ 

[1] Department of Chemical Engineering and Department of Applied Physics and Applied Mathematics Columbia University New York NY 10027 USA;Institute of Precision Medicine Peking University Shenzhen Hospital Shenzhen 518036 China;Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 117597 Singapore;

关键词: biomedical applications;    DNA conjugation;    DNA nanostructures;    DNA origami;    dynamic clusters;   

DOI  :  10.1002/advs.202003775

来源: DOAJ

【 摘 要 】

Abstract DNA is not only a carrier of genetic information, but also a versatile structural tool for the engineering and self‐assembling of nanostructures. In this regard, the DNA template has dramatically enhanced the scalability, programmability, and functionality of the self‐assembled DNA nanostructures. These capabilities provide opportunities for a wide range of biomedical applications in biosensing, bioimaging, drug delivery, and disease therapy. In this review, the importance and advantages of DNA for programming and fabricating of DNA nanostructures are first highlighted. The recent progress in design and construction of DNA nanostructures are then summarized, including DNA conjugated nanoparticle systems, DNA‐based clusters and extended organizations, and DNA origami‐templated assemblies. An overview on biomedical applications of the self‐assembled DNA nanostructures is provided. Finally, the conclusion and perspectives on the self‐assembled DNA nanostructures are presented.

【 授权许可】

Unknown