Dendrobium officinale polysaccharide attenuates type 2 diabetes mellitus via the regulation of PI3K/Akt-mediated glycogen synthesis and glucose metabolism

Journal of Functional Foods

Yu Zhang¹  Junfeng Wang²  Hanxiang Wang²  Hongjing Wang²  Kaiping Wang²  Yage Liu²  Weizhi Shui³  Ruxu You⁴  Peng Cao⁴ 

[1] Corresponding authors.;Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College of Huazhong University of Science and Technology, 430030 Wuhan, China;The Central Hospital of Wuhan of Huazhong University of Science and Technology, Department of Pharmacy, No. 26, Shengli Street, 430014 Wuhan, China;Union Hospital of Huazhong University of Science and Technology, Department of Pharmacy, No. 1227, Jiefang Road, 430030 Wuhan, China;

关键词: Dendrobium officinale;    Polysaccharide;    Glucose metabolism;    Glycogen synthesis;    Glucose metabolism enzymes;    PI3K/Akt signaling pathway;   

DOI  :  

来源: DOAJ

【 摘 要 】

This study aimed to explore the therapeutic effects of Dendrobium officinale polysaccharide (DOP), an active ingredient isolated from the water extract of Dendrobium officinale, in streptozotocin (STZ)-induced type 2 diabetic BALB/c mice and its potential mechanisms. Our results showed that DOP had beneficial effects in ameliorating hyperglycemia, insulin resistance and dyslipidemia. Additionally, DOP promoted glycogen synthesis via regulating the expression of glycogen synthase kinase 3 beta (GSK-3β), glycogen synthase (GS) and glucose transporter 4 (GLUT4) in the liver or muscle. Moreover, DOP reduced the blood glucose levels via the regulation of glucose metabolizing enzyme activity including pyruvate kinase (PK), hexokinase (HK) and phosphoenolpyruvate carboxykinase (PEPCK) in the liver. Furthermore, mechanistic studies illustrated that DOP could up-regulate the expression of PI3K/Akt signaling proteins both in vivo and in vitro. Our findings revealed that DOP improves glucose metabolism disorder by promoting glycogen synthesis and regulating the activity of glucose metabolism enzymes.

【 授权许可】

Unknown