Abietane-type diterpenoids from the roots of Salvia tebesana

Research Journal of Pharmacognosy

Z. Tayarani-Najaran¹  M. Iranshahi²  S. Eghbaliferiz*²  J. Asili²  S.A. Emami² 

[1] Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.;Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.;

关键词: abietane diterpenoid;    mass spectroscopy;    NMR;    Salvia tebesana;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background and objectives: The genus Salvia is one of the largest genera in the family Lamiaceae and represents approximately 1000 species displaying a remarkable diversity.Salvia tebesana Bunge(Lamiaceae) is an endemic medicinal species that grows wild in center of Iran which is locally named “Maryamgoli Tabasi”. Methods: The dried roots (2 kg) were perculated with MeOH at room temperature. Methanol extract was further fractionated to give four different fractions [n-hexane, dichloromethane (CH2Cl2), ethyl acetate (EtOAc) and water (H2O)]. In the next step, to afford the major bioactive compound(s) of the plant, the EtOAC extract was further sub-fractionated by silica gel column chromatography using a mixture of petroleum ether/ethyl acetate with increasing polarity. The different fractions were purified by reversed-phase semi-preparative HPLC. Results: From the ethyl acetate extract, two diterpene quinones with rearranged abietane skeletons, aegyptinones A and B were isolated and their structures were mainly elucidated by 1D and 2D NMR and mass spectroscopy. Conclusion: These compounds have been reported for the first time from this plant.

【 授权许可】

Unknown