期刊论文详细信息
BMC Infectious Diseases
Assessment of the effect of larval source management and house improvement on malaria transmission when added to standard malaria control strategies in southern Malawi: study protocol for a cluster-randomised controlled trial
Michèle van Vugt1  Michael G. Chipeta2  Kamija S. Phiri2  Steven Gowelo2  Alinune N. Kabaghe2  Themba Mzilahowa2  Nicolas Maire3  Aurelio Di Pasquale3  Peter J. Diggle4  Dianne J. Terlouw5  Willem Takken6  Henk van den Berg6  Monicah M. Mburu6  Robert S. McCann6 
[1] Academic Medical Centre, University of Amsterdam;College of Medicine, University of Malawi;Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute;Lancaster University;Liverpool School of Tropical Medicine;Wageningen University and Research;
关键词: Anopheles mosquitoes;    Integrated vector management;    Larval source management;    House improvement;    Vector control;    Malaria transmission;   
DOI  :  10.1186/s12879-017-2749-2
来源: DOAJ
【 摘 要 】

Abstract Background Due to outdoor and residual transmission and insecticide resistance, long-lasting insecticidal nets (LLINs) and indoor residual spraying (IRS) will be insufficient as stand-alone malaria vector control interventions in many settings as programmes shift toward malaria elimination. Combining additional vector control interventions as part of an integrated strategy would potentially overcome these challenges. Larval source management (LSM) and structural house improvements (HI) are appealing as additional components of an integrated vector management plan because of their long histories of use, evidence on effectiveness in appropriate settings, and unique modes of action compared to LLINs and IRS. Implementation of LSM and HI through a community-based approach could provide a path for rolling-out these interventions sustainably and on a large scale. Methods/design We will implement community-based LSM and HI, as additional interventions to the current national malaria control strategies, using a randomised block, 2 × 2 factorial, cluster-randomised design in rural, southern Malawi. These interventions will be continued for two years. The trial catchment area covers about 25,000 people living in 65 villages. Community participation is encouraged by training community volunteers as health animators, and supporting the organisation of village-level committees in collaboration with The Hunger Project, a non-governmental organisation. Household-level cross-sectional surveys, including parasitological and entomological sampling, will be conducted on a rolling, 2-monthly schedule to measure outcomes over two years (2016 to 2018). Coverage of LSM and HI will also be assessed throughout the trial area. Discussion Combining LSM and/or HI together with the interventions currently implemented by the Malawi National Malaria Control Programme is anticipated to reduce malaria transmission below the level reached by current interventions alone. Implementation of LSM and HI through a community-based approach provides an opportunity for optimum adaptation to the local ecological and social setting, and enhances the potential for sustainability. Trial Registration Registered with The Pan African Clinical Trials Registry on 3 March 2016, trial number PACTR201604001501493.

【 授权许可】

Unknown   

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