Experimental determination of the respiratory tract deposition of diesel combustion particles in patients with chronic obstructive pulmonary disease

Particle and Fibre Toxicology

关键词: Lung deposition;    Toxicity;    Health effects;    Air pollution;    Agglomerate;    Nanoparticles;    Aerosol;    COPD;    Diesel exhaust;   

DOI  :  10.1186/1743-8977-9-30

来源: DOAJ

【 摘 要 】

Abstract

Background

Air pollution, mainly from combustion, is one of the leading global health risk factors. A susceptible group is the more than 200 million people worldwide suffering from chronic obstructive pulmonary disease (COPD). There are few data on lung deposition of airborne particles in patients with COPD and none for combustion particles.

Objectives

To determine respiratory tract deposition of diesel combustion particles in patients with COPD during spontaneous breathing.

Methods

Ten COPD patients and seven healthy subjects inhaled diesel exhaust particles generated during idling and transient driving in an exposure chamber. The respiratory tract deposition of the particles was measured in the size range 10–500 nm during spontaneous breathing.

Results

The deposited dose rate increased with increasing severity of the disease. However, the deposition probability of the ultrafine combustion particles (< 100 nm) was decreased in COPD patients. The deposition probability was associated with both breathing parameters and lung function, but could be predicted only based on lung function.

Conclusions

The higher deposited dose rate of inhaled air pollution particles in COPD patients may be one of the factors contributing to their increased vulnerability. The strong correlations between lung function and particle deposition, especially in the size range of 20–30 nm, suggest that altered particle deposition could be used as an indicator respiratory disease.

【 授权许可】

Unknown