Patterning biomaterials for the spatiotemporal delivery of bioactive molecules

Frontiers in Bioengineering and Biotechnology

Francesca eTaraballi¹  Silvia eMinardi¹  Ennio eTasciotti¹  Laura ePandolfi² 

[1] Houston Methodist Research Institute;University of Chinese Academy of Science;

关键词: Tissue Engineering;    Drug delivery;    Biomimicry;    Biomaterials;    patterning;   

DOI  :  10.3389/fbioe.2016.00045

来源: DOAJ

【 摘 要 】

The aim of tissue engineering is to promote the repair of functional tissues. For decades, the combined use of biomaterials, growth factors, and stem cells has been at the base of several regeneration strategies. Among these, biomimicry emerged as a robust strategy to efficiently address this clinical challenge. Biomimetic materials, able to recapitulate the composition and architecture of the extracellular matrix, are the materials of choice, for their biocompatibility and higher rate of efficacy. In addition, it has become increasingly clear that restoring the complex biochemical environment of the target tissue is crucial for its regeneration. Towards this aim, the combination of scaffolds and growth factors is required. The advent of nanotechnology significantly impacted the field of tissue engineering by providing new ways to reproduce the complex spatial and temporal biochemical patterns of tissues. This review will present the most recent approaches to finely control the spatiotemporal release of bioactive molecules for various tissue engineering applications.

【 授权许可】

Unknown