Chinese herbal medicine for incomplete immune reconstruction in patients with AIDS undergoing antiretroviral treatment: A systematic review of randomized trials

Journal of Traditional Chinese Medical Sciences

Yajun Lian¹  Jing Li²  Jianping Liu³  Chen Shen³  Wenjing Zhang³  Fenglan Pu⁴  Lingyao Kong⁵  Huidi Lan⁶ 

[1] Fermentation Industries Co., Ltd, Beijing, 100015, China;;Beijing Key Laboratory of the Innovative Development of Functional Staple and the Nutritional Intervention for Chronic Disease, China National Research Institute of Food &Centre for Evidence Based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China;Ruikang Hospital, Guangxi University of Chinese Medicine, Nanning, 530001, China;School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 102488, China;School of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, 210023, China;

关键词: HIV;    AIDS;    Incomplete immune reconstruction;    Chinese herbal medicine;    Randomized clinical trials;    Systematic review;   

DOI  :  

来源: DOAJ

【 摘 要 】

Objective: To evaluate the effectiveness and safety of Chinese herbal medicines (CHMs) for incomplete immune reconstruction in patients with HIV/AIDS. Methods: Eight electronic databases were searched for randomized controlled trials (RCTs) on the use of CHM for patients with HIV/AIDS with incomplete immune reconstruction. Outcomes included CD4+ cell count, quality of life, and adverse events/effects. The Cochrane Risk of Bias was employed to evaluate the methodological quality of the included RCTs. Results: We identified 13 eligible RCTs, with an overall high risk of bias, on 10 different CHMs. There was a significant increase in CD4+ cell count after the use of Jianpi Yiqi medicinal paste for 3 months; tripterygium glycosides tablets (TGTs) for 3 months (mean difference [MD] 52.63 cells/μL, 95% confidence interval [CI, 46.98, 58.28]), 6, 9, and 12 months; Wenshen Jianpi granules for 6 months; Shenling Fuzheng capsules for 6 months (MD 49.53 cells/μL, 95% CI [8.45, 90.61]) and 12 months; Aikeqing granules for 9 months (MD 61.51 cells/μL, 95% CI [16.25, 106.77]) and 12 months; Guipi decoction for 12 months; Mianyi No.2 granules (JT) for 12 and 18 months; and Chinese medicine granules for 18 months. The increase in the mean difference of CD4+ cell count from 6 to 18 months was larger in Chinese medicine granules and Mianyi No.2 granules (JT). Guipi decoction and Jianpi Qushi decoction improved the Karnofsky score. Four RCTs reported the outcome of adverse events/effects, while four cases of minor adverse effects were reported in the TGTs group. Conclusion: Jianpi Yiqi medicinal paste, Wenshen Jianpi granules, Shenling Fuzheng capsules, Aikeqing granules, Guipi decoction, and TGTs may be effective in increasing CD4+ within 12 months, and Mianyi No.2 granules (JT) and Chinese medicine granules may show long-term effects. High-quality large RCTs on the effectiveness and safety of CHMs are still warranted.

【 授权许可】

Unknown