The Association of Renal Function and Plasma Metals Modified by EGFR and TNF-α Gene Polymorphisms in Metal Industrial Workers and General Population

International Journal of Environmental Research and Public Health

Joh-Jong Huang¹  Wei-Shyang Kung²  Tzu-Hua Chen³  Hung-Yi Chuang³  Jia-Yi Lu³  Hsiang-Ying Lee⁴  Kuei-Hau Luo⁵ 

[1] Department of Family Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan;Department of Pediatrics, Chien Shin Hospital, Kaohsiung 80143, Taiwan;Department of Public Health, College of Health Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;Department of Urology, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan;Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan;

关键词: health risk assessment;    toxic metals;    EGFR;    TNF-α;    single nucleotide polymorphism (SNP);    renal function;   

DOI  :  10.3390/ijerph18178965

来源: DOAJ

【 摘 要 】

Exposure to metals may be associated with renal function impairment, but the effect modified by genetic polymorphisms was not considered in most studies. Epidermal growth factor receptor (EGFR) and tumor necrotic factor-α (TNF-α) play important roles in renal hemodynamics, and they have been reported to be associated with some renal diseases. The aim of our research is to explore whether genetic variations in EGFR and TNF-α have influence on renal function under exposure to various metals. This cross-sectional study consisted of 376 metal industrial workers, 396 participants of Taiwan Biobank, and 231 volunteers of health examinations. We identified 23 single nucleotide polymorphisms (SNPs) on the EGFR gene and 6 SNPs on the TNF-α gene, and we also measured their plasma concentration of cobalt, copper, zinc, selenium, arsenic, and lead. Multiple regression analysis was applied to investigate the association between various SNPs, metals, and renal function. Our results revealed some protective and susceptible genotypes under occupational or environmental exposure to metals. The individuals carrying EGFR rs2280653 GG might have declined renal function under excessive exposure to selenium, and those with EGFR rs3823585 CC, rs12671550 CC, and rs4947986 GG genotypes might be susceptible to lead nephrotoxicity. We suggest the high-risk population to prevent renal diseases.

【 授权许可】

Unknown