Antifungal Activity of Essential Oil and Main Components from Mentha pulegium Growing Wild on the Chilean Central Coast

Agronomy

Katy Díaz¹  Bastián Said²  Ximena Besoain³  Iván Montenegro⁴  Patricio Godoy⁵  Carol Parra⁶  Alejandro Madrid⁷ 

[1] Departamento de Química, Universidad Técnica Federico Santa María, Av. España N° 1680, Valparaíso 2340000, Chile;Departamento de Química, Universidad Técnica Federico Santa María, Av. Santa María 6400, Vitacura, Santiago 7630000, Chile;Escuela de Agronomía Pontificia Universidad Católica de Valparaíso, Quillota, San Francisco s/n La Palma, Quillota 2260000, Chile;Escuela de Obstetricia y Puericultura, Facultad de medicina, Universidad de Valparaíso, Angamos 655, Reñaca, Viña del Mar 2520000, Chile;Instituto de Microbiología Clínica, Facultad de Medicina, Universidad Austral de Chile, Los Laureles s/n, Isla Teja, Valdivia 5090000, Chile;Laboratorio de Investigación en Nutrición y Alimentos (LINA), Departamento Disciplinario de Nutrición, Facultad de Ciencias de la Salud, Universidad de Playa Ancha, Valparaíso 2340000, Chile;Laboratorio de Productos Naturales y Síntesis Orgánica (LPNSO), Departamento de Química, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Avda. Leopoldo Carvallo 270, Playa Ancha, Valparaíso 2340000, Chile;

关键词: mentha pulegium;    botrytis cinerea;    monilinia fructicola;    antifungal activity;    essential oil;   

DOI  :  10.3390/agronomy10020254

来源: DOAJ

【 摘 要 】

Fungal diseases, both pre- and post-harvest, are currently difficult to control—increased antifungal resistances have further stimulated the search for natural alternatives. The objective of the present research work was to evaluate the antifungal activities of Mentha pulegium essential oil (EO) and its major constituents. The EO was obtained from hydro distillation of fresh leaves, and composition was determined using gas chromatography/mass spectrometry (GC/MS). The main components were identified as pulegone (29.33%), menthol (28.79%), menthone (20.48%), and isopulegol (9.75%). EO and isopulegol exhibited the highest antifungal activity, with half maximal effective concentrations (EC₅₀) inhibiting mycelial activity of Monilinia fructicola at 24.6 µg/mL and 20.8 µg/mL, respectively, and against Botrytis cinerea, at 301.45 µg/mL and 333.84 µg/mL, respectively. These findings could lay the foundation for developing antifungal agents of agricultural value.

【 授权许可】

Unknown