The Role of the Renal Dopaminergic System and Oxidative Stress in the Pathogenesis of Hypertension

Biomedicines

WaleedN. Qaddumi¹  PedroA. Jose² 

[1] Columbian College of Arts & Sciences, The George Washington University, Washington, DC 20052, USA;Department of Medicine and Department of Physiology/Pharmacology, Division of Renal Diseases & Hypertension, The George Washington University School of Medicine and Health Sciences, Washington, DC 20052, USA;

关键词: blood pressure;    dopamine;    dopamine receptor;    dopaminergic system;    hypertension;    kidney;   

DOI  :  10.3390/biomedicines9020139

来源: DOAJ

【 摘 要 】

The kidney is critical in the long-term regulation of blood pressure. Oxidative stress is one of the many factors that is accountable for the development of hypertension. The five dopamine receptor subtypes (D₁R–D₅R) have important roles in the regulation of blood pressure through several mechanisms, such as inhibition of oxidative stress. Dopamine receptors, including those expressed in the kidney, reduce oxidative stress by inhibiting the expression or action of receptors that increase oxidative stress. In addition, dopamine receptors stimulate the expression or action of receptors that decrease oxidative stress. This article examines the importance and relationship between the renal dopaminergic system and oxidative stress in the regulation of renal sodium handling and blood pressure. It discusses the current information on renal dopamine receptor-mediated antioxidative network, which includes the production of reactive oxygen species and abnormalities of renal dopamine receptors. Recognizing the mechanisms by which renal dopamine receptors regulate oxidative stress and their degree of influence on the pathogenesis of hypertension would further advance the understanding of the pathophysiology of hypertension.

【 授权许可】

Unknown