Dendritic cell derived cytokines in human natural killer cell differentiation and activation

Frontiers in Immunology

Obinna eChijioke¹  Christian eMuenz¹ 

[1] University of Zurich;

关键词: il-12;    Immunological Synapse;    IL-15;    IL-18;    DNAM-1;    IFN-alpha;   

DOI  :  10.3389/fimmu.2013.00365

来源: DOAJ

【 摘 要 】

Dendritic cells (DCs) and natural killer (NK) cells shape each other’s functions early during immune responses. DCs activate NK cells and NK cells can mature or kill DCs. In this review we will discuss which DC and NK cell subsets are mainly affected by this interaction, where these encounters might take place and which signals are exchanged. Finally, we will point out what the clinical benefit of understanding this interaction might be and how it changed our view on NK cells as innate lymphocytes.

【 授权许可】

Unknown