Dietary Egg Sphingomyelin Prevents Aortic Root Plaque Accumulation in Apolipoprotein-E Knockout Mice

Nutrients

GregoryH. Norris¹  CourtneyL. Millar²  Liya Anto²  ChristopherN. Blesso²  Addison Vitols²  Samantha Seibel²  Chelsea Garcia² 

[1] Department of Medicine, University of Illinois, Chicago, IL 60612, USA;Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA;

关键词: sphingolipids;    eggs;    atherosclerosis;    phospholipids;    cardiovascular;    microbiota;    diversity;    inflammation;   

DOI  :  10.3390/nu11051124

来源: DOAJ

【 摘 要 】

Western-style diets have been linked with dyslipidemia and inflammation, two well-known risk factors associated with cardiovascular disease (CVD). Dietary sphingomyelin (SM) has been reported to modulate gut microbiota, and lower serum lipids and inflammation in mice on Western-style diets. However, few studies have examined if nutritionally-relevant intake of dietary SM can impact atherosclerosis progression. Thus, the aim of this study was to determine if incorporating 0.1% (w/w) egg SM (ESM) (equivalent to ~750 mg/day in humans) into a high-fat (45% kcal), cholesterol-enriched diet (HFD) could prevent atheroprogression in apoE^−/− mice (n = 15/group). We found that mice fed with the ESM-rich diet had significantly lower epididymal fat mass (−46%) and tended to have higher spleen weights (+15%). There were no significant differences in serum lipids between groups. However, ESM-fed mice had significantly lower alanine aminotransferase (ALT) activity. Additionally, ESM-fed mice displayed significantly less aortic root lipid accumulation (−31%) compared to controls. This improvement in atherosclerosis was paired with over a two-fold reduction in circulating serum amyloid A (SAA) in ESM-fed mice. Finally, there was also a modulation of the gut microbiota with ESM supplementation. ESM may have the potential to prevent atherosclerosis, however further research in the clinical setting is warranted.

【 授权许可】

Unknown