Copper – a novel stimulator of autophagy

Cell Stress

Guido Kroemer¹  Hans Zischka² 

[1] Centre de Recherche des Cordeliers, Equipe labellisée par la Ligue contre le cancer, Université de Paris, Sorbonne Université, IN-SERM U1138, Institut Universitaire de France, Paris, France.;Institute of Molecular Toxicology and Pharmacology, Helmholtz Center Munich, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany.;

关键词: autophagy;    wilson disease;    copper;    cancer;    ulk1;    ulk2;    mek1;   

DOI  :  10.15698/cst2020.05.218

来源: DOAJ

【 摘 要 】

Toxic copper accumulation causes Wilson disease, but trace amounts of copper are required for cellular and organismal survival. In a recent paper Tsang et al. (Nat Cell Biol, doi: 10.1038/s41556-020-0481-4) demonstrate that copper binds with high affinity to a designated interaction site in the pro-autophagic kinases ULK1 and ULK2. Chelation of copper or genetic deletion of this copper-binding site inhibits autophagy and hence reduces the fitness of KRAS-induced cancers. These findings suggest that copper chelation might constitute a novel therapeutic intervention on autophagy-dependent malignancies.

【 授权许可】

Unknown