Effects of long-term supplementation with tetrahydrocurcumin and branched-chain amino acids on glucose tolerance and muscle protein content in mature rats

Journal of Physical Fitness and Sports Medicine

Toshihiko Osawa¹  Mika Mochizuki¹  Yoshiharu Shimomura²  Hiroshi Takayanagi²  Sanshiro Yamada²  Yasuyuki Kitaura² 

[1] Department of Health and Nutrition, Faculty of Psychological and Physical Science, Aichi Gakuin University;Laboratory of Nutritional Biochemistry, Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University;

关键词: tetrahydrocurcumin;    branched-chain amino acids;    glucose tolerance;    soleus muscle protein;    mature rats;   

DOI  :  10.7600/jpfsm.2.509

来源: DOAJ

【 摘 要 】

Maturation and aging induce alterations in glucose and protein metabolism, which are responsible for insulin resistance and sarcopenia. In the present study, we examined the effects of long-term (16 weeks) ingestion of diets supplemented with tetrahydrocurcumin (THC) and/or branched-chain amino acids (BCAAs) on glucose tolerance and soleus muscle protein content in mature rats (28 weeks of age). Intraperitoneal glucose tolerance tests (IPGTTs) were performed at week 6 and week 12 during the experimental period. Glucose tolerance was not affected by 6-week supplementation with THC and/or BCAAs, but was improved by supplementation at 12 weeks. A synergistic effect of THC and BCAAs was not observed. The protein content of the soleus muscle was increased by long-term supplementation with BCAAs, but not THC. These results suggest that THC and BCAAs are potentially beneficial supplements to improving maturation (aging)-related metabolic deterioration.

【 授权许可】

Unknown