Evaluating predictive relationships between wristbands and urine for assessment of personal PAH exposure

Environment International

Julie B. Herbstman¹  Antonia M. Calafat²  Darrell Holmes³  Lehyla Calero³  Haleigh M. Cavalier³  Elizabeth A. Gibson³  Kim A. Anderson³  Rachel L. Miller⁴  Laurel Kincl⁵  Diana Rohlman⁵  Holly M. Dixon⁶  Richard P. Scott⁶  Katrina M. Waters⁶  Lisa M. Bramer⁷ 

[1]Pacific Northwest National Laboratory, Biological Sciences Division, Richland, WA, USA

[2]Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Laboratory Sciences, Atlanta, GA, USA

[3]Columbia University, Columbia Center for Children’s Environmental Health, Department of Environmental Health Sciences, Mailman School of Public Health, New York City, NY, USA

[4]Icahn School of Medicine at Mount Sinai, Division of Clinical Immunology, New York City, NY, USA

[5]Oregon State University, College of Public Health and Human Sciences, Corvallis, OR, USA

[6]Oregon State University, Environmental and Molecular Toxicology, Food Safety and Environmental Stewardship Program, Corvallis, OR, USA

[7]Pacific Northwest National Laboratory, Biological Sciences Division, Richland, WA, USA

关键词: Predictive modeling;    Passive sampling;    Biomonitoring;    Disasters;    Exposome;   

DOI  :  

来源: DOAJ

【 摘 要 】

During events like the COVID-19 pandemic or a disaster, researchers may need to switch from collecting biological samples to personal exposure samplers that are easy and safe to transport and wear, such as silicone wristbands. Previous studies have demonstrated significant correlations between urine biomarker concentrations and chemical levels in wristbands. We build upon those studies and use a novel combination of descriptive statistics and supervised statistical learning to evaluate the relationship between polycyclic aromatic hydrocarbon (PAH) concentrations in silicone wristbands and hydroxy-PAH (OH-PAH) concentrations in urine. In New York City, 109 participants in a longitudinal birth cohort wore one wristband for 48 h and provided a spot urine sample at the end of the 48-hour period during their third trimester of pregnancy. We compared four PAHs with the corresponding seven OH-PAHs using descriptive statistics, a linear regression model, and a linear discriminant analysis model. Five of the seven PAH and OH-PAH pairs had significant correlations (Pearson’s r = 0.35–0.64, p ≤ 0.003) and significant chi-square tests of independence for exposure categories (p ≤ 0.009). For these five comparisons, the observed PAH or OH-PAH concentration could predict the other concentration within a factor of 1.47 for 50–80% of the measurements (depending on the pair). Prediction accuracies for high exposure categories were at least 1.5 times higher compared to accuracies based on random chance. These results demonstrate that wristbands and urine provide similar PAH exposure assessment information, which is critical for environmental health researchers looking for the flexibility to switch between biological sample and wristband collection.

【 授权许可】

Unknown