Salvianolic Acid B in Microemulsion Formulation Provided Sufficient Hydration for Dry Skin and Ameliorated the Severity of Imiquimod-Induced Psoriasis-Like Dermatitis in Mice

Pharmaceutics

Yu-Pin Cheng¹  Shiou-Hwa Jee¹  Chen-Yu Wu¹  Yang Lo¹  Haw-Yueh Thong²  Jiun-Wen Guo³  Chi-Jung Huang³  Chih-Yi Liu⁴ 

[1] Department of Dermatology, Cathay General Hospital, Taipei 10630, Taiwan;Department of Dermatology, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan;Department of Medical Research, Cathay General Hospital, Taipei 10630, Taiwan;Division of Pathology, Sijhih Cathay General Hospital, New Taipei City 22174, Taiwan;

关键词: interleukin-23;    interleukin-17;    psoriasis;    salvianolic acid B;    microemulsion;    imiquimod;   

DOI  :  10.3390/pharmaceutics12050457

来源: DOAJ

【 摘 要 】

Psoriasis is a chronic inflammatory skin disorder with a pathogenesis involving the interleukin-23/interleukin-17 axis. Salvianolic acid B exerts several pharmacological effects, such as antioxidation, anti-inflammation, and antitumor effects. The anti-psoriatic effects of salvianolic acid B have not been reported. In this study, we aimed to determine the optimum vehicle for salvianolic acid B, investigate its therapeutic effect on psoriatic-like skin conditions, and explore its underlying mechanisms of action. BALB/c mice were administered topical imiquimod to induce psoriasis-like skin and were then randomly assigned to control, vehicle control, salvianolic acid B in vehicles, and 0.25% desoximetasone ointment treatment groups. Barrier function, cytokine expression, histology assessment, and disease severity were evaluated. The results showed that salvianolic acid B-containing microemulsion alleviated disease severity, reduced acanthosis, and inhibited interleukin-23/interleukin-17 (IL-23/IL-17) cytokines, epidermal proliferation, and increased skin hydration. Our study suggests that salvianolic acid B represents a possible new therapeutic drug for the treatment of psoriasis. In addition, such formulation could obtain high therapeutic efficacy in addition to providing sufficient hydration for dry skin.

【 授权许可】

Unknown