Neurological manifestations of COVID-19: a systematic review

Critical Care

Gentle Sunder Shrestha¹  Dong Ya Huang²  Zhi Lan Tu³  Rajeev Ojha⁴  Gaurab Pokhrel⁵  Jayant Kumar Yadav⁶  Gaurav Nepal⁶  Yow Ka Shing⁷  Jessica Holly Rehrig⁸ 

[1] Department of Anesthesiology, Tribhuvan University Teaching Hospital;Department of Neurology, Shanghai East Hospital of Tongji University School of Medicine;Department of Neurology, Shanghai Pudong Hospital, Fudan University Pudong Medical Center;Department of Neurology, Tribhuvan University Teaching Hospital;Department of Urology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology;Maharajgunj Medical Campus, Tribhuvan University Institute of Medicine;National University Hospital;University of New England College of Osteopathic Medicine;

关键词: COVID-19;    SARS-CoV-2;    Neurological manifestation;    Brain;   

DOI  :  10.1186/s13054-020-03121-z

来源: DOAJ

【 摘 要 】

Abstract Introduction Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global spread of coronavirus disease (COVID-19). Our understanding of the impact this virus has on the nervous system is limited. Our review aims to inform and improve decision-making among the physicians treating COVID-19 by presenting a systematic analysis of the neurological manifestations experienced within these patients. Methods Any study, released prior to May 20, 2020, that reported neurological manifestations in patients infected by SARS-CoV-2 was systematically reviewed using the PRISMA (Preferred Reporting Items for Systemic review and Meta-Analysis) statement. Results Our systematic review included data from 37 articles: twelve retrospective studies, two prospective studies, and the rest case reports/series. The most commonly reported neurological manifestations of COVID-19 were myalgia, headache, altered sensorium, hyposmia, and hypogeusia. Uncommonly, COVID-19 can also present with central nervous system manifestations such as ischemic stroke, intracerebral hemorrhage, encephalo-myelitis, and acute myelitis, peripheral nervous manifestations such as Guillain-Barré syndrome and Bell’s palsy, and skeletal muscle manifestations such as rhabdomyolysis. Conclusion While COVID-19 typically presents as a self-limiting respiratory disease, it has been reported in up to 20% of patients to progress to severe illness with multi-organ involvement. The neurological manifestations of COVID-19 are not uncommon, but our study found most resolve with treatment of the underlying infection. Although the timeliness of this review engages current challenges posed by the COVID-19 pandemic, readers must not ignore the limitations and biases intrinsic to an early investigation.

【 授权许可】

Unknown