Microbubbles and Nanobubbles with Ultrasound for Systemic Gene Delivery

Pharmaceutics

Yoko Endo-Takahashi¹  Yoichi Negishi¹ 

[1] Department of Drug Delivery and Molecular Biopharmaceutics, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan;

关键词: ultrasound-mediated delivery;    microbubble;    nanobubble;    gene delivery;    theranostics;   

DOI  :  10.3390/pharmaceutics12100964

来源: DOAJ

【 摘 要 】

The regulation of gene expression is a promising therapeutic approach for many intractable diseases. However, its use in clinical applications requires the efficient delivery of nucleic acids to target tissues, which is a major challenge. Recently, various delivery systems employing physical energy, such as ultrasound, magnetic force, electric force, and light, have been developed. Ultrasound-mediated delivery has particularly attracted interest due to its safety and low costs. Its delivery effects are also enhanced when combined with microbubbles or nanobubbles that entrap an ultrasound contrast gas. Furthermore, ultrasound-mediated nucleic acid delivery could be performed only in ultrasound exposed areas. In this review, we summarize the ultrasound-mediated nucleic acid systemic delivery system, using microbubbles or nanobubbles, and discuss its possibilities as a therapeutic tool.

【 授权许可】

Unknown