Diagnostic accuracy of red blood cell distribution width-to-lymphocyte ratio for celiac disease

Romanian Journal of Laboratory Medicine

Popp Alina¹  Beata Acs²  Balaban Daniel Vasile³  Jinga Mariana³  Vasilescu Florina⁴ 

[1] “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania “Alessandrescu-Rusescu” National Institute for Mother and Child Health, Bucharest, Romania Tampere Center for Child Health Research, University of Tampere and Tampere University Hospital, Bucharest, Romania;“Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania “Alessandrescu-Rusescu” National Institute for Mother and Child Health, Bucharest, Romania;“Dr. Carol Davila” Central Military Emergency University Hospital, Bucharest, Romania “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania;“Dr. Carol Davila” Central Military Emergency University Hospital, Bucharest, Romania;

关键词: celiac disease;    screening;    red blood cell distribution width;    lymphopenia;   

DOI  :  10.1515/rrlm-2017-0040

来源: DOAJ

【 摘 要 】

Background. Celiac disease (CD) is significantly underdiagnosed, despite significant efforts made in the last decades to increase its diagnostic rate. This has lead to a high need for developing new diagnostic strategies. Our aim was to evaluate the diagnostic performance of two routine hematologic indices for CD. Methods. In a prospective observational study, 34 newly diagnosed CD patients, 34 age-sex matched controls with irritable bowel syndrome (IBS) and 16 treated CD patients were assessed regarding the differences in mean lymphocyte count (LY), red blood cell distribution width (RDW) and their ratio (RDW/LY).Results. Elevated RDW (>14) and lymphopenia (<1.5 x 10e9/L) were more frequently seen in newly diagnosed CD patients compared to IBS control group and treated CD patients. Newly diagnosed CD patients had significantly higher mean values of RDW/LY - 10.09, compared to 7.72 in the CD-treated group and 6.79 in IBS controls (p<0.01). Subgroup analysis revealed that RDW/LY was higher in patients with destructive histology (Marsh≥3a), 10.54 vs. 7.99. For a value over 7, RDW/LY had a sensitivity of 88.24% (95% CI 72.55-96.70%) and AUROC of 0.785 (95% CI 0.683- 0.887). Conclusions. RDW/LY ratio is a widely available tool which could be used routinely in clinical practice for CD screening.

【 授权许可】

Unknown