Some aspects of treatment for cognitive impairments. Cyticolin: pharmacological characteristics, possible benefits, aspects of use

Nevrologiâ, Nejropsihiatriâ, Psihosomatika

I. S. Preobrazhenskaya¹  N. V. Trofimova¹ 

[1] I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia;

关键词: cyticolin;    cognitive impairments;    neurodegeneration;    neuroprotective effect;    sirtuins;    alzheimer’s disease;    parkinson’s disease;   

DOI  :  10.14412/2074-2711-2015-4-65-70

来源: DOAJ

【 摘 要 】

The paper reviews the data available in the literature on the pharmacokinetic and pharmacodynamic properties of cyticolin and its use in cognitive impairments (CIs).It assesses trials investigating the effect of cyticolin on cognitive functions, including its possible role in increasing Sirtuin 1 (SIRT1) expression. The results of the latest multicenter trials of the drug used to treat dementia syndrome are analyzed in elderly patients with clinical presentations of mental confusion (the VITA trial) and mild vascular CIs (the IDEALE trial).Cyticolin is able to potentiate neuroplasticity and is a natural precursor of phospholipids, mainly phosphotidylcholine that serves as a source of choline in the metabolic pathways of acetylcholine biosynthesis. The VITA and IDEALE have shown that the parenteral and oral administrations of cyticolin are effective and safe in the treatment of moderate vascular CIs and dementia with clinical presentations of mental confusion. Cyticolin therapy is used to reduce the risk of side effects and to delay of loss of the therapeutic effects of levodopa preparations. Cyticolin has been noted to have a positive effect on cognitive functions in patients with Alzheimer’s disease if it is used as an additional therapy.

【 授权许可】

Unknown