Host Microbe Interactions in the Lactating Mammary Gland

Frontiers in Microbiology

Nabil Bosco¹  Olga Sakwinska² 

[1] Nestlé Research Singapore Hub, Singapore, Singapore;Nestlé Research, Nestlé Institute of Health Sciences, Lausanne, Switzerland;

关键词: human milk;    mucosal surface;    microbiome;    lactation;    breastfeeding;    mastitis;   

DOI  :  10.3389/fmicb.2019.01863

来源: DOAJ

【 摘 要 】

The bacteria present in human milk constitute the human milk microbiome (hMM). Both the older culture-based work and the more recent studies using molecular detection of bacterial DNA have reached similar conclusions: the hMM mostly consists of commensal staphylococci such as Staphylococcus epidermidis, and streptococci. The prevalence of other bacterial groups such lactobacilli varies widely, while the abundance and prevalence of bifidobacteria is generally low. Recently, the hMM became accepted as a part of a physiologically normal state with suggested potential health benefits. Most research on the hMM has focused on its composition and potential effect on the breastfed infant. A major role as a microbiome inoculum for the infant gut has been proposed, but remains to be clearly demonstrated. Herein, we also discuss the emerging connection between the hMM and mammary gland physiology and lactation. Similarities between the mammary gland and mucosal interfaces are considerable, and in particular mucosal-like immune attributes of mammary gland. The potential role of hMM-host interactions in the mammary gland in maternal health is explored with a primary focus on lactational mastitis.

【 授权许可】

Unknown