Current status of insecticide resistance among malaria vectors in Kenya

Parasites & Vectors

Simon M. Muriu¹  Luna Kamau²  Christopher Nyundo³  Charles M. Mbogo³  Joseph M. Mwangangi³  Benyl M. Ondeto³  Evan M. Mathenge⁴  Kiambo Njagi⁵  Horace Ochanda⁶ 

[1] Department of Biological Sciences, Pwani University;KEMRI, Centre for Biotechnology Research and Development;KEMRI, Centre for Geographic Medicine Research, Coast & KEMRI Wellcome Trust Research Programme;KEMRI, Eastern and Southern Africa Centre of International Parasite Control;Ministry of Health, Malaria Control Unit;School of Biological Sciences, University of Nairobi;

关键词: Insecticide resistance;    Mechanism of resistance;    Anopheles;    Malaria;    Kenya;   

DOI  :  10.1186/s13071-017-2361-8

来源: DOAJ

【 摘 要 】

Abstract Background Insecticide resistance has emerged as one of the major challenges facing National Malaria Control Programmes in Africa. A well-coordinated national database on insecticide resistance (IRBase) can facilitate the development of effective strategies for managing insecticide resistance and sustaining the effectiveness of chemical-based vector control measures. The aim of this study was to assemble a database on the current status of insecticide resistance among malaria vectors in Kenya. Methods Data was obtained from published literature through PubMed, HINARI and Google Scholar searches and unpublished literature from government reports, research institutions reports and malaria control programme reports. Each data source was assigned a unique identification code and entered into Microsoft Excel 2010 datasheets. Base maps on the distribution of insecticide resistance and resistance mechanisms among malaria vectors in Kenya were generated using ArcGIS Desktop 10.1 (ESRI, Redlands, CA, USA). Results Insecticide resistance status among the major malaria vectors in Kenya was reported in all the four classes of insecticides including pyrethroids, carbamates, organochlorines and organophosphates. Resistance to pyrethroids has been detected in Anopheles gambiae (s.s.), An. arabiensis and An. funestus (s.s.) while resistance to carbamates was limited to An. gambiae (s.s.) and An. arabiensis. Resistance to the organochlorine was reported in An. gambiae (s.s.) and An. funestus (s.s.) while resistance to organophosphates was reported in An. gambiae (s.l.) only. The mechanisms of insecticide resistance among malaria vectors reported include the kdr mutations (L 1014S and L 1014F) and elevated activity in carboxylesterase, glutathione S-transferases (GST) and monooxygenases. The kdr mutations L 1014S and L 1014F were detected in An. gambiae (s.s.) and An. arabiensis populations. Elevated activity of monooxygenases has been detected in both An. arabiensis and An. gambiae (s.s.) populations while the elevated activity of carboxylesterase and GST has been detected only in An. arabiensis populations. Conclusions The geographical maps show the distribution of insecticide resistance and resistance mechanisms among malaria vectors in Kenya. The database generated will provide a guide to intervention policies and programmes in the fight against malaria.

【 授权许可】

Unknown