Epigenetic Regulation in Kidney Transplantation

Frontiers in Immunology

Jiefu Zhu¹  Guie Dong²  Zheng Dong²  Xiaohong Xiang³ 

[1] Center of Nephrology and Dialysis, Transplantation, Renmin Hospital of Wuhan University, Wuhan, China;Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood Veteran Affairs (VA) Medical Center, Augusta, GA, United States;Department of Critical Care Medicine, The Second Xiangya Hospital, Central South University, Changsha, China;Department of Nephrology, Hunan Key Laboratory of Kidney Disease and Blood Purification, The Second Xiangya Hospital of Central South University, Changsha, China;

关键词: kidney transplantation;    epigenetic regulation;    DNA methylation;    acetylation;    non-coding RNAs;   

DOI  :  10.3389/fimmu.2022.861498

来源: DOAJ

【 摘 要 】

Kidney transplantation is a standard care for end stage renal disease, but it is also associated with a complex pathogenesis including ischemia-reperfusion injury, inflammation, and development of fibrosis. Over the past decade, accumulating evidence has suggested a role of epigenetic regulation in kidney transplantation, involving DNA methylation, histone modification, and various kinds of non-coding RNAs. Here, we analyze these recent studies supporting the role of epigenetic regulation in different pathological processes of kidney transplantation, i.e., ischemia-reperfusion injury, acute rejection, and chronic graft pathologies including renal interstitial fibrosis. Further investigation of epigenetic alterations, their pathological roles and underlying mechanisms in kidney transplantation may lead to new strategies for the discovery of novel diagnostic biomarkers and therapeutic interventions.

【 授权许可】

Unknown