Identifying asymptomatic Leishmania infections in non-endemic villages in Gedaref state, Sudan

BMC Research Notes

Hussam A. Osman¹  Emmanuel Edwar Siddig²  Rihab A. Omer³  Mohamed Siralkhatim Ali⁴  Mohamed S. Muneer⁵  Nouh Saad Mohamed⁶  Ayman Ahmed⁷  Arwa H. Elaagip⁷  Muzamil M. Abdel Hamid⁷  Abdallah M. Samy⁸  Anwar O. Mohammed⁹ 

[1]Biomedical Research Laboratory, Ahfad University for Women

[2]Department of Basic Medical Sciences, Faculty of Medical Laboratory Sciences, University of Khartoum

[3]Department of Molecular Biology, Institute of Zoology, University of Hohenheim

[4]Department of Molecular Biology, National University Research Institute, National University

[5]Department of Neurology, Mayo Clinic

[6]Department of Parasitology and Medical Entomology, Faculty of Medical Laboratory Sciences, University of Sinner

[7]Department of Parasitology and Medical Entomology, Institute of Endemic Diseases, University of Khartoum

[8]Entomology Department, Faculty of Science, Ain Shams University

[9]Malaria Control Program and Vector Control, Gedaref Ministry of Health

关键词: Visceral leishmaniasis;    Asymptomatic infection;    Non-endemic villages;    Gedaref state;    Sudan;   

DOI  :  10.1186/s13104-019-4608-2

来源: DOAJ

【 摘 要 】

Abstract Objectives Infection with the causative agent of visceral leishmaniasis (VL) may be either symptomatic or asymptomatic. In this study we aimed at investigating the prevalence of asymptomatic infections of leishmania in non-endemic villages in Gedaref state, Sudan. A descriptive cross-sectional study conducted during September and October 2014. Blood samples were collected for serological and molecular analysis. Sticky-traps, knockdown spray and CDC-miniature light traps were used for the collection of sandflies. Results Ninety-Five participants were included; 52 from Abukishma, 15 Algadamblia Tirfa, 25 Abualnaja and 3 were from Algadamblia Aljabal. Females constituted 56 (58.9%) of the study participants while males were 39 (41.1%). The most frequent age group was > 40-years (54.7%). Balanites/Acacia trees were the most planted tree inside the houses; 78 (82.1%). Also, 85 (89.5%) of the participants breed animals inside the house. DAT test revealed 5 positive participants (5.2%). 4/5 DAT positive were past VL infection. PCR detected 35 (36.8%) positive participants. A total of 31/35 was considered asymptomatic infections based on PCR. Households planted Balanites/Acacia trees or breed domestic animals were found in high percentages with L. donovani PCR positive participants (60.1%, 91.4%). No statistically significant was found for VL associated risk factors and VL asymptomatic participants.

【 授权许可】

Unknown