Sex-Related Differences in Patients With Unexplained Syncope and Bundle Branch Block: Lower Risk of AV Block and Lesser Need for Cardiac Pacing in Women

Frontiers in Cardiovascular Medicine

Ivo Roca-Luque¹  Jesús Rodríguez-Silva²  Gabriel Pascual-González²  Jaume Francisco-Pascual³  Jordi Pérez-Rodon³  Alba Santos-Ortega³  Javier Cantalapiedra-Romero³  Nuria Rivas-Gándara³  Begoña Benito³  Ignacio Ferreira-González⁴  Àngel Moya-Mitjans⁵  Manel Maymi-Ballesteros⁶  Antonia Sambola-Ayala⁶  Montserrat Bach-Oller⁶  Clara Badia-Molins⁶ 

[1] Arrhythmia Section, Institut Clinic Cardiovascular, Hospital Clínic, Barcelona, Spain;Arrhythmia Unit, Cardiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain;CIBER de Enfermedades Cardiovasculares (CIBERCV), Instituto de Salud Carlos III, Madrid, Spain;CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain;Cardiology Department, Hospital Universitari Dexeus, Barcelona, Spain;Cardiology Department, Hospital Universitari Vall d'Hebron, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Barcelona Hospital Campus, Barcelona, Spain;Department of Medicine, Universitat Autònoma de Barcelona, Bellaterra, Spain;

关键词: syncope;    pacemaker;    electrophysiological study;    loop recorder;    cardiac monitor;    gender differences;   

DOI  :  10.3389/fcvm.2022.838473

来源: DOAJ

【 摘 要 】

ObjectiveTo analyze if there are sex-related differences in patients with unexplained syncope and bundle branch block (BBB).BackgroundDespite increasing awareness that sex is a major determinant of the incidence, etiology, and the outcomes of different arrhythmias, no studies have examined differences in presentation and outcomes between men and women with syncope and BBB.MethodsCohort study of consecutive patients with unexplained syncope and BBB was included from January 2010 to January 2021 with a median follow-up time of 3.4 years [interquartile range (IQR) 1.7–6.0 years]. They were evaluated by a stepwise workup protocol based on electrophysiological study (EPS) and long-term follow-up with an implantable cardiac monitor (ICM).ResultsOf the 443 patients included in the study, 165 (37.2%) were women. Compared with men, women had less diabetes (25.5 vs. 39.9%, p = 0.002) and less history of ischemic heart disease (IHD; 13.3 vs. 25.9%, p = 0.002). Left bundle branch block (LBBB) was more frequent in women (55.2 vs. 27.7%, p < 0.001) while right bundle branch block (RBBB) was more frequent in men (41.5 vs. 67.7%, p < 0.001). His to ventricle (HV) interval in the EPS was shorter in women (58 ms [IQR 52–71] vs. 60 ms [IQR 52–73], p = 0.035) and less women had an HV interval longer than 70 ms (28.5 vs. 38.1%, p = 0.039), however, EPS and ICM offered a similar diagnostic yield in both sexes (40.6 vs. 48.9% and 48.4% vs. 51.1%, respectively). Women had a lower risk of developing atrioventricular block (AVB) (adjusted odds ratio [OR] 0.44–95% CI 0.26–0.74, p = 0.002) and of requiring permanent pacemaker implantation (adjusted hazard ratio [HR] 0.72–95% CI: 0.52–0.99, p = 0.046). The mortality rate was lower in women (4.5 per 100 person-years [95% CI 3.1–6.4 per 100 person-years] vs. 7.3 per 100 person-years [95% CI 5.9–9.1 per 100 person-years]).ConclusionsCompared to men, women with unexplained syncope and BBB have a lower risk of AVB and of requiring cardiac pacing. A stepwise diagnostic approach has a similar diagnostic yield in both sexes, and it seems appropriate to guide the treatment and avoid unnecessary pacemaker implantation, especially in women.

【 授权许可】

Unknown