Association of bisphenol A, bisphenol F, and bisphenol S with ADHD symptoms in children

Environment International

Bung-Nyun Kim¹  Youn-Hee Lim²  Young Ah Lee³  Choong Ho Shin³  Yun-Chul Hong⁴  Johanna Inhyang Kim⁵ 

[1] Environmental Health Center, Seoul National University College of Medicine, Seoul, Korea;Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul, South Korea;Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea;Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea;Department of Psychiatry, Hanyang University Medical Center, Seoul, Korea;

关键词: Attention deficit hyperactivity disorder;    Bisphenol A;    Bisphenol F;    Bisphenol S;    Children;   

DOI  :  

来源: DOAJ

【 摘 要 】

Background: Bisphenol A (BPA) has been linked to attention-deficit/hyperactivity disorder (ADHD) symptoms, but the neurotoxic effects of bisphenol substitutes such as bisphenol F (BPF) and S (BPS) have not been well investigated. We investigated the associations between BPA, BPF, and BPS with ADHD symptoms at multiple time points in children. Methods: The levels of BPA (at ages 4, 6, and 8), BPF (at ages 6 and 8), and BPS (at ages 6 and 8) were measured in 619 children. Because of the low detection frequency of BPF and BPS levels, participants were divided into categories (97%), whereas BPF and BPS were less frequently detected (age 6: 17.5% for BPF and 42.0% for BPS; age 8: 51.6% for BPF and 73.3% for BPS). Doubling in BPA levels was associated with increased ARS scores by 4.7% (95% confidence intervals [CI]: 0.5, 9.2) at age 6. The association was greater with BPA levels higher than 3.0 μg/g creatinine (24.2% [95% CI: 15.5, 33.6] increase). The BPF ≥ LOD group had 10.8% (95% CI: 1.2, 21.4) higher ARS scores than the BPF < LOD group. The BPS ≥ median group had 11.4% (95% CI: 2.0, 21.7) higher ARS scores than the BPS < LOD group. Conclusion: All bisphenols, in particular those at or above the LOD or median levels, were associated with ADHD symptoms at age 6. Further prospective studies are warranted to determine causal inference.

【 授权许可】

Unknown