Antioxidant, Anti-Inflammatory and Antidiabetic Proprieties of LC-MS/MS Identified Polyphenols from Coriander Seeds

Molecules

Amal A. Alotaibi¹  Mohammed Al-zharani²  ElHamsas El Youbi Amal³  Hamza Mechchate⁴  Imane Es-safi⁴  Hicham Bekkari⁴  Amal Amaghnouje⁴  Dalila Bousta⁴  Smahane Boukhira⁴  Omar M. Noman⁵  Fahd A. Nasr⁵  Raffaele Conte⁶ 

[1] Basic Science Department, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia;Biology Department, College of Science, Imam Mohammad ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia;Laboratory of Biology and Health, Faculty of Sciences Ben M’Sik, Hassan II-Casablanca University, Casablanca 20000, Morocco;Laboratory of Biotechnology, Environment, Agrifood, and Health, University of Sidi Mohamed Ben Abdellah, FSDM-Fez 47963, Morocco;Medicinal Aromatic, and Poisonous Plants Research Centre, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia;Research Institute on Terrestrial Ecosystems (IRET)—CNR, Via Pietro Castellino 111, 80131 Naples, Italy;

关键词: Coriandrum sativum L.;    polyphenols;    antioxidant propriety;    anti-inflammatory;    antidiabetic;    antihyperlipidemic;   

DOI  :  10.3390/molecules26020487

来源: DOAJ

【 摘 要 】

Coriandrum sativum L. seeds are traditionally used to treat diabetes and its complications (inflammation and formation of reactive oxygen species) around the world. The present study investigates the antidiabetic, anti-inflammatory, and antioxidant effects of the polyphenol fraction of Coriandrum sativum seeds (PCS). Diabetic mice were orally administered with PCS (25 and 50 mg/kg b.w.) for 28 days. Oral glucose tolerance (OGTT) was also evaluated along with the anti-inflammatory effect, assessed by measuring paw edema development induced with carrageenan in Wistar rat and the antioxidant activity assessed using two tests (β-carotene discoloration and DPPH). Treatment of diabetic mice with PCS for four weeks managed their high fasting blood glucose levels, improved their overall health, also revealed an excellent antihyperlipidemic activity. The OGTT result showed a potent antihyperglycemic activity, and following the anti-inflammatory and antioxidant effects, the PCS exhibited a perfect activity. LC-MS/MS result revealed the presence of 9 polyphenols. This modest work indicates that the PCS have an important antidiabetic, antihyperglycemic, antihyperlipidemic, anti-inflammatory, and antioxidant effect that can be well established treatment of diabetes and its complications.

【 授权许可】

Unknown