Merging Heterocyclic Chemistry and Biocatalysis in One-Pot Processes through Compartmentalization of the Reaction Steps

Bioengineering

Nadine Zumbrägel¹  Harald Gröger¹ 

[1] Chair of Organic Chemistry I, Faculty of Chemistry, Bielefeld University, Universitätsstraße 25, 33615 Bielefeld, Germany;

关键词: Asinger-type multi-component reaction;    asymmetric synthesis;    biocatalysis;    cascades;    compartmentalization;    heterocycles;   

DOI  :  10.3390/bioengineering5030060

来源: DOAJ

【 摘 要 】

A proof of concept for a one-pot process merging a heterocycle formation by a classical chemical approach at basic conditions with a biocatalytic reduction, running at neutral pH conditions, is reported. A crucial component for this process is the compartmentalization of the single reactions by the use of polydimethylsiloxane thimbles. This process was applied successfully towards an asymmetric synthesis of (S)-2,2,3-trimethyl-1-thia-4-azaspiro[4.4]nonane, leading to excellent enantioselectivities of 99% enantiomeric excess (ee).

【 授权许可】

Unknown